The brothers are known for designing clothes and staging elaborate fashion shows with "explosive energy". They design men's and women's apparel, men's and women's footwear and etc. A runway show in 2005 ended with Christina Aguilera stripping male models of their clothes. In January 2010, the DSquared2 Autumn/Winter 2010 menswear show in Milan featured Bill Kaulitz descending from the ceiling in a caged elevator A la Rocky Horror Picture Show, followed by a runway walk. Bill Kaulitz opened and closed the Dsquared2 Autumn/Winter 2010 menswear show in Milan.
Their designs have been worn by Britney Spears, Madonna, Tokio Hotel's lead singer Bill Kaulitz, Justin Timberlake, Ricky Martin, Nicolas Cage, and Lenny Kravitz. In 2000-2001, Madonna commissioned them to design over 150 pieces for her Drowned World Tour 2001 and "Don't Tell Me" music video. DSquared2's design was also featured in Britney Spears' Circus tour and Tokio Hotel's Welcome to Humanoid City tour.